Synthesis and biological evaluation of neopyrrolomycin analogs.
نویسندگان
چکیده
منابع مشابه
Synthesis and antibacterial activities of less chlorinated analogs of neopyrrolomycin.
structurally unique phenylpyrrole antibiotic. 1} Very recently, ( +)and (~)-neopyrrolomycins (1)2) and their analogs3) were synthesized from 3,5-dichloroanisole in our laboratories.4) Herein we report the synthesis of a variety of less chlorinated analogs (2 14) and their structure-activity relationship. All analogs (2~14) were synthesized from 2aminoanisoles 15a~15d by our procedures as report...
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this work is presented in five parts. in the first part preparation of the starting complex [pt(c^n)cl(dmso)], 1, in which c^n = n(1),c(2?)-chelated, deprotonated 2-phenylpyridine, and dmso = dimethylsulfoxide, and its reaction with 1 equiv of the biphosphine ligands bis(diphenylphosphino)amine, dppa, or bis(diphenylphosphino)methane, dppm, to give the complex [pt(c^n)cl(dppa)], 2, or [pt(c^n)c...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1994
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.47.262